By rray, 21 June, 2024 If early latent syphilis 1 eval mucosal surfaces oral cavity perianal area perineum vagina beneath foreskin for lesions test for HIV If neuro or ocular s sx present 2 eval for neurosyphilis
By rray, 21 June, 2024 If initial CSF pleocytosis repeat CSF exam q6mo until cell count normal if CSF cell count not darr after 6mo or if cell count protein not normal after 2y consider re tx
By rray, 21 June, 2024 After completion of neurosyphilis tx consider benzathine penicillin G 2 4 MU IV qwk x3 after to provide total duration of tx comparable to latent syphilis tx
By rray, 21 June, 2024 Tx neurosyphilis ocular syphilis1 w IV aqueous crystalline penicillin G 18 24 MU day divided 3 4 MU IV q4h or via continuous infusion x10 14 days2
By rray, 21 June, 2024 Alternative if compliance ensured Procaine penicillin G 2 4 MU IM qd probenecid 500 mg PO qid both x10 14 days