procainamide 1 g IV over 30min then 2 mg min over 1h Less effective than ibutilide AEs granulocytosis AV block HFrEF exacerbation hypotension neutropenia QT prolongation rash thrombocytopenia TdP Avoid if initially treated w amiodarone or ibutilide Consid

<a href=https://online.epocrates.com/e/deeplink/drugs/10a68/procainamide><u>procainamide</u></a> (1 g IV over 30min, then 2 mg/min over 1h). Less effective than ibutilide. AEs: granulocytosis, AV block, HFrEF exacerbation, hypotension, neutropenia, QT prolongation, rash, thrombocytopenia, TdP. Avoid if initially treated w/ amiodarone or ibutilide. Consider only if ibutilide or amiodarone not optimal. Considered safe in pregnancy.