If on LAMA LABA If eos 100 cells L consider ICS LAMA LABA If eos

<b>If on LAMA+LABA:</b> If eos ≥100 cells/µL, consider ICS+LAMA+LABA. If eos <100 cells/µL: If FEV₁ <50% w/ chronic bronchitis, consider roflumilast (improves lung fxn, reduces exac [A]); if not a current smoker, consider azithromycin (reduces exac [A]but increases bacterial resistance [A]and impairs hearing [B]).