If U urate plus hyperuricemia 380 mol L give alkaline citrate 3 10 g day plus allopurinol 100 300 mg day 2nd line tx febuxostat 80 mg day Strong 1

If ↑U urate plus hyperuricemia (>380 µmol/L), give alkaline citrate 3-10 g/day plus allopurinol 100-300 mg/day; 2nd-line tx: febuxostat 80 mg/day [Strong]¹