Detail (Long)
Choose tx based on side-effect profile, in the context of shared decision-making. [CP]<br>
◦ <b>Antimuscarinics:</b> common: dry mouth, constipation, voiding dysfunction/incomplete emptying, retention, blurred vision; rare: palpitations, tachycardia, and QT prolongation, which can lead to torsades de pointes. ER superior to IR formulations for ↓ side effects.<br>
◦ <b>β3 agonists:</b> may have fewer side effects than antimuscarinics, esp. dry mouth and constipation, and less effect on PVR, resulting in ↓rates of voiding dysfunction, but may affect CV function; mirabegron not recommended if severe, uncontrolled HTN (SBP ≥180 mmHg or DBP ≥110 mmHg).
◦ <b>Antimuscarinics:</b> common: dry mouth, constipation, voiding dysfunction/incomplete emptying, retention, blurred vision; rare: palpitations, tachycardia, and QT prolongation, which can lead to torsades de pointes. ER superior to IR formulations for ↓ side effects.<br>
◦ <b>β3 agonists:</b> may have fewer side effects than antimuscarinics, esp. dry mouth and constipation, and less effect on PVR, resulting in ↓rates of voiding dysfunction, but may affect CV function; mirabegron not recommended if severe, uncontrolled HTN (SBP ≥180 mmHg or DBP ≥110 mmHg).