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<sup>5</sup> If not high-intensity statin candidate, use mod-intensity tx like for >75 yo w/ AS-CVD.<br><br>
<sup>6</sup> It is reasonable to intensify statin tx to achieve at least a 50% LDL-C reduction [E]. After max statin intensity achieved, it is reasonable to add a nonstatin drug to further reduce LDL-C [E].
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<sup>7</sup> Atorvastatin 40 mg: evidence from 1 RCT only after down-titration from 80 mg due to intolerance.
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<sup>8</sup> Rosuvastatin 40 mg not included in RCTs.
<sup>6</sup> It is reasonable to intensify statin tx to achieve at least a 50% LDL-C reduction [E]. After max statin intensity achieved, it is reasonable to add a nonstatin drug to further reduce LDL-C [E].
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<sup>7</sup> Atorvastatin 40 mg: evidence from 1 RCT only after down-titration from 80 mg due to intolerance.
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<sup>8</sup> Rosuvastatin 40 mg not included in RCTs.
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