Glycemic goal in many nonpregnant adults is A1C <7%⁴ [B]

³ If metformin not tolerated or is contraindicated, consider initial drug from other classes.<br><br>⁴ More stringent A1C goal (<6.5%) may be considered in pts w/ short duration of DM, pts treated w/ lifestyle or metformin only, long life expectancy, no CV risk factors [C]. Less stringent A1C goal (<8%) may be appropriate for pts w/ hx of severe hypoglycemia, limited life expectancy, advanced complications, extensive comorbidity, etc [B].