By rray, 14 June, 2024 FHx factors assoc w increased likelihood of potentially harmful BRCA mutations 1 nbsp nbsp Breast CA dx in family member
By rray, 14 June, 2024 Gail Model Not recommended by ACS 6 Limitations limited use in non White population not for age
By rray, 14 June, 2024 CanRisk Tool BOADICEA v5 Limitations limited use in non White population routine use of polygenic risk scores in risk assessment not encouraged does not consider personal risk factors like breastfeeding prior breast bx atypia Does not include hx of rad tx
By rray, 14 June, 2024 The Breast Cancer Surveillance Consortium BCSC Risk Calculator v 2 0 Limitations not applicable if 74 yo prior breast CA dx DCIS breast augmentation mastectomy Does not consider beyond 1st deg relatives 4
By rray, 14 June, 2024 BRCAPRO ACS approved 6 Limitations underestimates carrier frequency in families w ovarian prostate CA Stats for minority pt populations need improvement Does not incorporate 3rd deg relatives Excludes limited or unknown fam info Ages must be estimated if
By rray, 14 June, 2024 International Breast Cancer Intervention Study instrument Tyrer Cuzick ACS approved 6 Limitations does not consider risk from prior rad tx overestimates risk of breast CA in Hispanics AH LCIS dense breasts Routine use of polygenic risk scores in risk asse