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<b>Start long- or short-acting BD.</b> Long-acting preferred unless SOB is only occasional [A]. <b>Inhaled is preferred vs. oral</b> [A]. Regular and prn SAMA or SABA use improves FEV<sub>1</sub> and sx [A]; SABA+SAMA combos more effective than mono-tx [A]. LABAs and LAMAs improve dyspnea, reduce exac rate [A]. LAMAs reduce exac [A]and hospitalizations [B]more than LABAs; combos more effective than mono-tx [B]. Tailor choice of inhaler to pt’s ability and preference. Minimize number of devices.