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<b>If stable w/ marked hypercapnia, consider NPPV.</b> NPPV may improve hospital-free survival in select pts post-recent hospitalization, esp. if daytime PaCO<sub>2</sub> >53 mmHg [B]. Long-term NPPV beneficial in pts w/ severe chronic hypercapnia and hx of hospitalization for acute resp failure [B]. If COPD+OSA, CPAP has clear benefits.