International Breast Cancer Intervention Study instrument Tyrer Cuzick ACS approved 6 Limitations does not consider risk from prior rad tx overestimates risk of breast CA in Hispanics AH LCIS dense breasts Routine use of polygenic risk scores in risk asse

<b>International Breast Cancer Intervention Study instrument (Tyrer-Cuzick).</b> ACS-approved.⁶ Limitations: does not consider risk from prior rad tx; overestimates risk of breast CA in Hispanics, AH, LCIS, dense breasts. Routine use of polygenic risk scores in risk assessment not encouraged.⁴