If 20 high ASCVD risk Initiate high intensity 50 LDL C lowering statin tx nbsp nbsp atorvastatin 40 80 mg qd nbsp nbsp rosuvastatin 20 40 mg qd Atorvastatin and rosuvastatin interact w ritonavir and cobicistat boosted ARVs If pregnant Defer statin tx init

If ≥20% (high) ASCVD risk:<br>
• Initiate high-intensity (≥50% LDL-C–lowering) statin tx:<br>
&nbsp;&nbsp;◦ <a href=https://online.epocrates.com/e/deeplink/drugs/10a879/atorvastatin><u>atorvastatin</u></a> 40-80 mg qd<br>
&nbsp;&nbsp;◦ <a href=https://online.epocrates.com/e/deeplink/drugs/10a3476/rosuvastatin><u>rosuvastatin</u></a> 20-40 mg qd<br>
• Atorvastatin and rosuvastatin interact w/ ritonavir- and cobicistat-boosted ARVs.<br>
• If pregnant: Defer statin tx initiation until after pregnancy in pts at low to intermediate ASCVD risk. If on statin tx, discontinue. Breastfeeding is <i>not</i> recommended while on statin tx.<br><br>