Consider individual risks benefits race FHx comorbidities risks of dx tx 9 etc nbsp nbsp High risk if age 50 yo 6 10 prostate CAs are found in pts 65 yo 11 African American or Caribbean of African ancestry 2A 8 11 12 FHx of prostate CA esp sibling11 even

Consider individual risks/benefits, race, FHx, comorbidities, risks of dx/tx,⁹ etc.<br>
&nbsp;&nbsp;◦ High risk if: age >50 yo (~6/10 prostate CAs are found in pts >65 yo);¹¹ African American, or Caribbean of African ancestry [2A];^8,11,12 FHx of prostate CA, esp. sibling¹¹ (<b>even higher risk</b> if ≥2 first-deg relatives w/ prostate CA before age 65⁵); known gene variants/mutations—<i>BRCA1/BRCA2</i>, <i>CHEK2</i>, <i>ATM</i>, <i>PALB2</i>, Lynch syndrome (HNPCC), <i>HOXB13</i> (refer to genetics specialist) [2A];^11,12 agent orange exposure [2A].¹²<br>
&nbsp;&nbsp;◦ Less certain risk factors:¹¹ diet high in dairy, animal fats;¹⁰ arsenic exposure;¹¹ firefighter chemical exposure;¹¹ EtOH use.¹⁰ Conflicting evidence: prostatitis, STIs, vasectomy.¹¹ Other possible dietary factors:¹⁰ selenium, vitamin E, vitamin D, lycopene, and isoflavones.